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KMID : 0616120190500030185
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 3 p.185 ~ p.190
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Anti-inflammatory Effect of Eucommia Ulmoides Oliver Bark Extract on P.gingivalis LPS-induced YD-38 Cells
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Kim Ye-Jin
Heo Woong
Choi Han-Seok
Kang Ji-Sung
Hwang Gwi-Seo
Baek Ji-Yun
Koo Bon-Am
Kim Hyun-Young
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Abstract
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Periodontitis is a chronic inflammatory disease and gums pull away from the teeth and form spaces. The main goal of treatment is to control the infection and anti-inflammation. Eucommia ulmoides Oliv. Bark (EU) is a traditional Korean herbal used for the treatment of arthritis and hypertension. In the present study, we investigated the anti-inflammatory properties of EU in Porphyromonas gingivalis-LPS (LPS-PG) induced YD-38 epithelial cells. We observed significant inhibition of nitric oxide (NO) production and the expression of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-a), cyclooxygenase-2 (COX-2) in LPS-PG-induced YD-38 cells. These results support that EU has an anti-inflammatory effects for the treatment of periodontitis.
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KEYWORD
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Periodontitis, Eucommia ulmoides oliv. bark (EU), Anti-inflammation, Porphyromonas gingivalis-lps (LPS-PG), YD-38 cells
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